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Effect of aspartame loading upon plasma and erythrocyte amino acid levels in phenylketonuric heterozygotes and normal adult subjects  [1979]

Stegink, Lewis D. Filer, L.J. Baker, George L. McDonnell, Jean E.

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ملخص
Aspartame is a dipeptide with a sweetening power 180 to 200 times that of sucrose. Questions about aspartame safety have arisen because of concern about potential toxic effects of its constituent amino acids, aspartate and phenylalanine, particularly in subjects heterozygous for phenylketonuria (PKU). (Children with untreated PKU are mentally retarded.) Plasma and red cell amino acid levels were measured in eight female subjects known to be heterozygous for phenylketonuria and 12 subjects assumed to be normal after aspartame administration (34 mg/kg) in orange juice. No changes in either plasma or erythrocyte aspartate levels were noted at any time after aspartame loading in either group, indicating rapid metabolism of the aspartame administered. Maximum plasma phenylalanine levels were only slightly above values noted postprandially in the human infant and adult. Erythrocyte phenylalanine levels showed similar, but smaller changes. The data indicated slightly slower, but adequate metabolism and clearance of the phenylalanine portion of aspartame by the phenylketonuric heterozygote
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Other information

اللغة : English

النوع : Journal Article

In AGRIS since : 1981

Volume : 109

Issue : 4

Start Page : 708

End Page : 717

All titles :

" Effect of aspartame loading upon plasma and erythrocyte amino acid levels in phenylketonuric heterozygotes and normal adult subjects "