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Post-antibiotic effect of Amoxicillin nanoparticles against main pathogenic bacteria of Bovine mastitis in vitro  [2009]

Yang Xuefeng, Northernwest Agriculture and Forestry University, Yangling (China), College of Veterinary Medicine Ouyang Wuqing, Northernwest Agriculture and Forestry University, Yangling (China), College of Veterinary Medicine Sun Jiangcai, Northernwest Agriculture and Forestry University, Yangling (China), College of Veterinary Medicine

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Abstract
The post-antibiotic effect (PAE) of Amoxicillin nanoparticles(AMX-NP)against pathogenic bacteria of bovine mastitis in vitro was studied. These bacteria mainly included S. aureus ATCC25923 and its isolates from veterinary clinic, S. agalactiae, E. coli ATCC25922 and its isolates from veterinary clinic. The minimal inhibitory concentration (MIC) and the minimal bactericidal concentration (MBC) of AMX-NP against these pathogenic bacteria were measured by tube double dilution method after the preparation of AMX-NP. By the microscope direct counting method of the bacteria the PAE of AMX-NP against every bacterium was determined at the concentration of 0.5×MIC, 1×MIC, 2×MIC and 4×MIC respectively during the PAE of AMX-NP. At the concentration of 0.5×MIC, 1×MIC, 2×MIC and 4×MIC the marked PAE was all found when AMX-NP were used. The value of PAE was enhanced with the increasing concentration, showing strongly concentration-dependent, and the value of PAE against S. aureus and S. agalactiae was higher than that of PAE against E. coli. Longer dosing interval should be recommended when AMX-NP were used for the prevention and cure of bovine mastitis by S. aureus and S. agalactiae. However, shortened dosing interval or successive dosing should be taken when they were used against sensitive E. coli.
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Other subjects

  • ganado de leche
  • dairy cattle
  • mastitis
  • mammite
  • penicilina
  • penicillins
  • bovin laitier
  • penicilline

From the journal

Journal of Northwest Agriculture and Forestry University(Natural Science Edition)

ISSN : 1671-9387

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