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Written Paper

Anti-inflammatory Activity of Aristotelia chilensis Mol. (Stuntz) (Elaeocarpaceae)  [2010]

Carlos L. CÉSPEDES Julio ALARCON Jose G. AVILA Antonio NIETO

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Context: "Chilean Black-berry" Aristotelia chilensis is a wild fruit that growth in southern Chile. This fruit possess a strong antioxidant activity and is commonly used in foods and beverages in Chile. Objective: The anti-inflammatory activity of the extracts, fractions and subfractions of this fruit are investigated here for the first time. Materials and methods: Extracts, fractions and subfractions were analyzed for their content in total phenolics and the effects in the TPA-induced inflammation in ear of the mouse ear edema induced by single doses of TPA were investigated. In addition, the antioxidant activity was investigated against DPPH, Crocin and TBARS. Results: The results showed that extract B, fraction F-4, and ovatifolin, quercetin, myricetin, luteolin and diosmetin used as pattern compounds were the most active samples together with those subfractions rich in phenolic compounds. Thus, SF11-SF15, SF16-SF20, and SF21-SF25 showed are the best subfractions inhibitors in similar form to indomethacin a known selective COX inhibitor that have an EI50 of 0.11 mg/ear. Results demonstrated that these samples strongly inhibited the induced inflammation in ear of the mouse edema in TPA inflammation model, with EC50 values ranging from 0.3 to 11.8 ¿g/mL. Discussion and conclusion: These findings demonstrate that the fruits and their constituents of A. chilensis have excellent anti-inflammatory activities and thus have great potential as a source for natur
al health products. Additionally, these findings showed that the flavonoids, phenolic acids and anthocyanins present in this fruit may be responsible of the antioxidant activity observed.

From the journal

Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas

ISSN : 0717-7917

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