Written Paper

Flukicidal and Nematocidal Efficacy of Pamizole Super (Closantel + Tetramisole) and Distomicida (Closantel) in Naturally Infested Ethiopian Zebu Cattle.  [1990]

Feseha Gebreab and Yilma Jobre Ethiopian Journal of Agricultural Sciences [Corporate Author]

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The efficacy of Pamizole Super against Fasciola hepatica, gastrointestinal helminths, and Dictocaulus viviparis and that of Distomicida against F. hepatica was studied on 16 naturally infested adult Ethiopian zebu cattle. Experimental animals were divided into two groups of six each plus four control animals, designated as group 1 (Pamizole Super treated), group 2 (Distomicida treated), and group 3 (untreated control). Weekly fecal examinations indicated a decline in Fasciola egg output in all groups of animals up to the second week, and a rise in groups 1 and 2 on the third week after treatment. For gastroinations strongyles, the mean egg per gram feces counts were 0 for group 1, 67 for group 2, and 59 for group 3. No larvae of D. vivparus were detected from group 1animals after treatment, but the only positive animal in group 3 was continuously shedding larvae. Postmortem examination revealed that the mean worm counts for F. hcpalica for the three groups were 90, 65, and 85. Adult worms recovered were intact, motile and not stunted. The efficacy of Pamizole Super against natural infections was 0 for F. hepatica, 100% for H. placei, 94.5% for Oesophagostomum spp., and 100% for D. viviparus. Tlie efficacy of Distomicida against the first three parasites was 27.4%, 100%, and 11.1% respectively. Tin' poor efficacy of the two drugs against F. hepatica is attributed to their mechanisms of action. Their further use as flukicides in Ethiopia and generally on hyp
oproleinemic and stress-subjected animals is not recommended.

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Ethiopian Journal of Agricultural Sciences