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Long-term effects of dietary alpha-linolenic acid from perilla oil on serum fatty acids composition and on the risk factors of coronary heart disease in Japanese elderly subjects  [1999]

Ezaki, O. (National Inst. of Health and Nutrition, Tokyo (Japan)) Takahashi, M. Shigematsu, T. Shimamura, K. et al.

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Abstract
Although important roles of dietary n-3 fatty acids in the revention of coronary heart disease (CHD) have been suggested, long-term effects of dietary alpha-linolenic acid (ALA, 18:3/3n-3) have not yet been established under controlled conditions. We tested whether a moderate increase of dietary ALA affects fatty acids composition in serum and the risk factors of CHD. Oxidized LDL (OxLDL) was directly measured by ELISA using antibody specific to OxLDL. By merely replacing soybean cooking oil (SO) with perilla oil (PO) (i.e., increasing 3 g/d of ALA), the n-6/n-3 ratio in the diet was changed from 4:1 to 1:1. Twenty Japanese elderly subjects were initially given a SO diet for at least 6 mo (baseline period), a PO diet for 10 mo (intervention period), and then returned to the previous SO diet (washout period). ALA in the total serum lipid increased from 0.8 to 1.6% after 3mo on the PO diet, but EPA and DHA increased in a later time, at 10 mo after the PO diet, from 2.5 to 3.6% and 5.3 to 6.4%, respectively (p0.05), and then returned to baseline in the washout period. In spite of increases of serum n-3 fatty acids, the OxLDL concentration did not change significantly when given the PO diet. Body weight, total serum cholesterol, triacylglycerol, glucose, insulin and HbAlc concentrations, platelet count and aggregation function, prothrombin time, partial thromboplastin time, fibrinogen and PAI-1 concentration, and other routine blood analysis did not cha
nge significantly when given the PO diet. These data indicate that, even in elderly subjects, a 3 g/d increase of dietary ALA could increase serum EPA and DHA in 10 mo without any major adverse effects
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Other subjects

  • risque
  • fatty acids
  • japan
  • elderly
  • aceites vegetales
  • acidos grasos
  • suero sanguineo
  • tercera edad
  • cardiopathie
  • riesgo
  • linolenic acid
  • blood serum
  • heart diseases
  • acide gras
  • personne agee
  • risk
  • huile vegetale
  • acide linolenique
  • japon
  • perilla
  • plant oils
  • acido linolenico
  • enfermedades cardiacas
  • serum sanguin

From the journal

Journal of Nutritional Science and Vitaminology (Japan)

ISSN : 0301-4800

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Other information

Language : English

Type : Summary

In AGRIS since : 2001

Volume : 45

Issue : 6

Start Page : 759

End Page : 772

All titles :

" Long-term effects of dietary alpha-linolenic acid from perilla oil on serum fatty acids composition and on the risk factors of coronary heart disease in Japanese elderly subjects "