Written Paper

Screening of Anti-angiogenic Activity from Plant Extracts  [2006]

Kim, J.S. (AngioLab, Inc., Daejeon, Republic of Korea) Park, B.Y. (AngioLab, Inc., Daejeon, Republic of Korea) Park, E.K. (AngioLab, Inc., Daejeon, Republic of Korea) Lee, H.S. (AngioLab, Inc., Daejeon, Republic of Korea) et al.

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We examined anti-angiogenic effects of water extracts from 32 plant materials (20 Korean medicinal plants and 12 western herbs) using cell-based anti-angiogenic assay, HUVEC tube formation assay, and then we found that 7 plant extracts inhibited HUVEC tube formation strongly. The plant materials which showed anti-angiogenic effects are Cinnamomi Ramulus, Atractylodis Rhizoma alba, Polygalae Racix, Myristicae Semen, Artemisiae Iwayomogii Herba, leaves of Rosmarinus officinalis, an leaves of Melissa officinalis. We also investigated inhibitory effects of these anti-angiogenic herbal extracts on MMP (matrix metalloproteinase) activity which has important roles in angiogenesis.

From the journal

Korean Journal of Pharmacognosy

ISSN : 0253-3073