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Assessment of the Potential Allergenicity of Genetically Modified Soybeans and Soy-based Products

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Shon, D.H. (Korea Food Research Institute, Sungnam, Republic of Korea)
Kim, T.W. (Kyung Hee University, Suwon, Republic of Korea)
Lee, S.I. (Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea)
Kim, H.Y. (Kyung Hee University, Suwon, Republic of Korea), E-mail: hykim@khu.ac.kr
Kim, D.O. (Kyung Hee University, Suwon, Republic of Korea)
Ahn, K.M. (Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea)
Lieu, H.Y. (Kyung Hee University, Suwon, Republic of Korea)
Kim, J.H. (Kyung Hee University, Suwon, Republic of Korea)

Abstract:
A comprehensive safety evaluation was conducted to assess the potential allergenicity of newly introduced proteins in genetically modified (GM) crops. We assessed the allergenicity of CP4 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) in GM soybeans. This assessment was performed by IgE immunoblotting with soy-allergic children's sera, amino acid sequence homology with known allergens, and the digestibility of CP4 EPSPS. No differences in IgE-antigen binding by immunoblotting were found between GM soy samples and the corresponding non-GM samples.





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