Written Paper

Neuroprotective Lignans from Biota orientalis leaves  [2008]

Yoon, J.S. (Seoul National University, Seoul, Republic of Korea) Koo, K.A. (Inje University, Gimhae, Republic of Korea) Ma, C.J. (Kangwon National University, Chuncheon, Republic of Korea) Sung, S.H. (Seoul National University, Seoul, Republic of Korea) et al.

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We previously reported that 90% MeOH fraction of Biota orientalis leaves (L.) ENDL. had significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells. In the present study, (-)-savinin (1), (-)-hinokinin (2), dehydroheliobuphthalmin (3) were isolated by bioactivity-guided fractionation from the 90% MeOH fraction. All three lignans had significant neuroprotective activities against glutamate-induced neurotoxicity at the concentrations ranging from 0.1 to 10.0 μM.

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Natural Product Sciences

ISSN : 1226-3907