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Flavone Biotransformation by Aspergillus niger and the Characterization of Two Newly Formed Metabolites  [2008]

Mahmoud, Yehia A.G. (Tanta University, Tanta, Egypt), E-mail: Yehiamah@gmail.com Assawah, Suzan W. (Tanta University, Tanta, Egypt) El-Sharkawy, Saleh H. (Al Mansoura University, Al Mansoura, Egypt) Abdel-Salam, Amal (Tanta University, Tanta, Egypt)

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Abstract
Aspergillus niger isolated from Allium sativum was used at large scale fermentation (150 mg flavone/200ml medium) to obtain suitable amounts of the products, efficient for identification. Then spectral analysis (UV, IR, ¹H-NMR, ∨13C-NMR) and mass spectrometry were performed for the two products, which contributed to the identification process. The metabolite (1) was identified as 2'-hydroxydihydrochalcone, and the metabolite (2) was identified as 2'-hydroxyphenylmethylketone, which were more active than flavone itself. Antioxidant activities of the two isolated metabolites were tested compared with ascorbic acid. Antioxidant activity of metabolite (1) was recorded 64.58% which represented 79% of the antioxidant activity of ascorbic acid, and metabolite (2) was recorded 54.16% (67% of ascorbic acid activity). However, the antioxidant activity of flavone was recorded 37.50% which represented 46% of ascorbic acid activity. The transformed products of flavone have anti-microbial activity against Pseudomonas aeruginosa, Aspergillus flavus and Candida albicans, with MIC was recorded 250 ㎍/ml for metabolite (2) against all three organism and 500, 300, and 300 ㎍/ml for metabolite (1) against tested microorganisms (P. aeruginosa, Escherichia coli, Bacillus subtilis, and Klebsiella pneumonia, Fusarium moniliforme, A. flavus, Saccharomyces cerviceae, Kluveromyces lactis and C. albicans) at this order.
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Other subjects

  • antioxydant
  • antioxidants
  • Biotransformation
  • flavonoides
  • flavonoide
  • aspergillus
  • flavonoids
  • antioxidantes
  • Anit-microbial

From the journal

Mycobiology

ISSN : 1229-8093

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Other information

Language : English

Type : Directory

In AGRIS since : 2010

Volume : 36

Issue : 2

Start Page : 121

End Page : 133

All titles :

" Flavone Biotransformation by Aspergillus niger and the Characterization of Two Newly Formed Metabolites "