Flavone Biotransformation by Aspergillus niger and the Characterization of Two Newly Formed Metabolites  [2008]

Mahmoud, Yehia A.G. (Tanta University, Tanta, Egypt), E-mail: Yehiamah@gmail.com Assawah, Suzan W. (Tanta University, Tanta, Egypt) El-Sharkawy, Saleh H. (Al Mansoura University, Al Mansoura, Egypt) Abdel-Salam, Amal (Tanta University, Tanta, Egypt)

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Aspergillus niger isolated from Allium sativum was used at large scale fermentation (150 mg flavone/200ml medium) to obtain suitable amounts of the products, efficient for identification. Then spectral analysis (UV, IR, ¹H-NMR, ∨13C-NMR) and mass spectrometry were performed for the two products, which contributed to the identification process. The metabolite (1) was identified as 2'-hydroxydihydrochalcone, and the metabolite (2) was identified as 2'-hydroxyphenylmethylketone, which were more active than flavone itself. Antioxidant activities of the two isolated metabolites were tested compared with ascorbic acid. Antioxidant activity of metabolite (1) was recorded 64.58% which represented 79% of the antioxidant activity of ascorbic acid, and metabolite (2) was recorded 54.16% (67% of ascorbic acid activity). However, the antioxidant activity of flavone was recorded 37.50% which represented 46% of ascorbic acid activity. The transformed products of flavone have anti-microbial activity against Pseudomonas aeruginosa, Aspergillus flavus and Candida albicans, with MIC was recorded 250 ㎍/ml for metabolite (2) against all three organism and 500, 300, and 300 ㎍/ml for metabolite (1) against tested microorganisms (P. aeruginosa, Escherichia coli, Bacillus subtilis, and Klebsiella pneumonia, Fusarium moniliforme, A. flavus, Saccharomyces cerviceae, Kluveromyces lactis and C. albicans) at this order.

Other subjects

  • antioxydant
  • antioxidants
  • Biotransformation
  • flavonoides
  • flavonoide
  • aspergillus
  • flavonoids
  • antioxidantes
  • Anit-microbial

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ISSN : 1229-8093


Other information

Language : English

Type : Directory

In AGRIS since : 2010

Volume : 36

Issue : 2

Start Page : 121

End Page : 133

All titles :

" Flavone Biotransformation by Aspergillus niger and the Characterization of Two Newly Formed Metabolites "