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Antiglycemic Effect of Carnosine in Diabetic Mice  [2009]

Hue, J.J., Chungbuk National University, Cheongju, Republic of Korea Kim, J.S., Chungbuk National University, Cheongju, Republic of Korea Kim, J.H., Chungbuk National University, Cheongju, Republic of Korea Nam, S.Y., Chungbuk National University, Cheongju, Republic of Korea et al.

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Abstract
Carnosine is a dipeptide (β-alanyl-L-histidine) found in mammalian brain, eye, olfactory bulb and skeletal muscle at high concentrations. Its biological functions include antioxidant and anti-glycation activities. The objectives of this study were to investigate anti-diabetic effects of carnosine as determined by blood glucose levels in glucose tolerance test (GTT) and insulin tolerance test (ITT), insulin level and serum biochemical and lipid levels in male C57BL/6J db/db mice. There were five experimental groups including normal (C57BL/6J), control (vehicle), and three groups of carnosine at doses of 6, 30, and 150 mg/kg b.w. Carnosine was orally administered to the diabetic mice everyday for 8 weeks. There was no significant difference in body weight changes in carnosine-treated groups compared to the control. The treatments of carnosine significantly decreased the blood glucose level in the diabetic mice compared with the control (p less than 0.05) after 5 weeks. The treatments of carnosine also significantly decreased the blood glucose levels in GTT and ITT and glycosylated hemoglobin (HbA1c), compared with the control (p less than 0.05). Carnosine at the dose of 6 mg/kg significantly decreased the serum insulin level compared to the control (p less than 0.05). Carnosine significantly increased total proteins but significantly decreased lactate dehydrogenase and blood urea nitrogen compared with the control (p less than 0.05). Carnosine also significa
ntly decreased glucose, LDL, and triglyceride in the serum of diabetic mice compared to the control (p less than 0.05). These results suggest that carnosine has a hypoglycermic effect resulting from reduction of glucose and lipid levels and that high carnosine-containing diets or drugs may give a benefit for controlling diabetes mellitus in humans.
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Other subjects

  • diabete
  • insuline
  • carnosine
  • insulin
  • blood sugar
  • sucre du sang
  • diabetes
  • azucar en sangre
  • insulina

From the journal

Journal of Food Hygiene and Safety

ISSN : 1229-1153

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