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Anti-inflammatory Activity of Dichloromethane Extract of Auricularia auricula-judae in RAW264.7 Cells  [2011]

Damte, Dereje, Kyungpook National University, Daegu, Republic of Korea Reza, Md. Ahsanur, Kyungpook National University, Daegu, Republic of Korea Lee, S.J., Kyungpook National University, Daegu, Republic of Korea Jo, W.S., Gyeongbuk Agricultural Technology Administration, Daegu, Republic of Korea et al.

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Abstract
The present study investigated the anti-inflammatory effects of dichloromethane extract of Auricularia auricula-judae. Dichloromethane extract of Auricularia auricula-judae inhibited Lipopolysaccharide (LPS)-induced nitric oxide (NO) production significantly in a dose-dependent manner in the concentration greater-than or equal to 10 ㎍/ml (p less than 0.05). Furthermore, RT-PCR results of this study indicated that the extract markedly reduced the expressions of inflammatory cytokines (IL-6, TNF-α and IL-1β) mRNA in LPS-treated murine RAW 264.7 macrophages, which could possibly ameliorate the inflammation. Nevertheless, dichloromethane extract of Auricularia auricula-judae did not show complete inhibition of IL-6 mRNA expression. The inhibition of IL-1β cytokine at protein level was also observed in a dose dependent manner. In conclusion, the current study revealed the previously unknown effect of dichloromethane ethyl extract of Auricularia auricula-judae inhibitions of the production of NO, IL-6, TNF-α and IL-1β in LPS-stimulated macrophages.
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Other subjects

  • oxido nitrico
  • Auricularia auricula-judae
  • nitric oxide
  • Inflammatory cytokines
  • oxyde nitrique
  • Anti-inflammatory
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Other information

Language : English

Type : Directory

In AGRIS since : 2012

Volume : 27

Issue : 1

Start Page : 11

End Page : 14

All titles :

" Anti-inflammatory Activity of Dichloromethane Extract of Auricularia auricula-judae in RAW264.7 Cells "