In vitro Anti-malarial Activity of Juniperus Chinensis Extract  [2012]

Lee, K.H., Korea Prime Pharm., Suwon, Republic of Korea Kim, B.S., Kongju National University, Yesan, Republic of Korea Choe, Y.H., Kongju National University, Yesan, Republic of Korea Rhee, K.H., Kongju National University, Yesan, Republic of Korea

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This study was carried out to investigate the anti-malarial activity of Juniperus chinensis by in vitro and in vivo system using Plasmodium falciparum chloroquine-sensitive(3D7) and P. falciparum chloroquine-resistant(S20) strains. According to cytotoxicty test on NIH 3T3 cell, the ethanol extract(EtOH), ethylacetate(EtOAc) fraction and aqueous fraction possessed significant anti-malarial activity against both 3D7 and S20 strains at non-toxic concentrations(less than100 /). In vitro assay, EtOAc fraction showed notable activity against 3D7 and S20 strains of P. falciparum with IC∧50 values of 37±2 ㎍/ml and 36±6 ㎍/ml. In animal test using P. falciparum infected human erythrocytes, the treatment of EtOAc fraction significantly inhibited parasitaemia in mice in a dose-dependent manner that is parasitaemia of 42%, 34% and 31% in doses of 10 mg/kg, 20 mg/kg and 40 mg/kg, respectively. The study provides data to support the medicinal importance of the J. chinensis.

Other subjects

  • plasmodium falciparum
  • Juniperus chinensis
  • malaria

From the journal

Korean Journal of Pharmacognosy

ISSN : 0253-3073