Cytotoxicity studies of Eurycoma longifolia extracts against a panel of human cancer cell lines  [2002]

Nurhanan Murni Yunos, Forest Research Institute Malaysia (FRIM), 52109 Kepong, Kuala Lumpur (Malaysia). Medicinal Plant Division Azimahtol H.L.P., Kebangsaan Malaysia Univ. (UKM), 43600 UKM, Bangi, Selangor (Malaysia). Faculty Science and Technology. School of Biosciences and Biotechnology Azizol A.K., Forest Research Institute of Malaysia (FRIM), 52109 Kepong, Selangor (Malaysia). Medicinal Plant Division

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Eurycoma longifolia (Tongkat Ali) is a species in the family Simaroubaceae that has a characteristic bitter taste. Extracts from E. longifolia's roots were obtained through a successive extraction procedure. The cytotoxicity studies were carried out on the crude extracts as well as the partitioning products against a panel of human cancer cell lines with the methylene blue bioassay. The cell lines tested were prostate tumour (DU-145), pelvic (RD) epidermoid carcinoma (KB) and normal Chang's liver. Methanolic (ME) extract showed a significant cytotoxic effect (IC50 ≤ 20.0 µg/ml) against RD and KB, however, it did not show any significant cytotoxic effect against DU-145 (IC50 = 33.0 mg/ml). Petroleum ether (PE) and aqueous (AE) extracts showed insignificant cytotoxic effect (IC50 20.0 µg/ml) against all the cancer cell lines tested. No toxic effect was observed for these extracts when treated on the normal Chang's liver cell line. These fi ndings suggested that E. longifolia extract particularly ME might contain some active phytochemicals that have anti-cancer property.

Other subjects

  • toxicity
  • ensayo biologico
  • extractos
  • extrait
  • cellule
  • malaysia
  • neoplasme
  • malasia
  • simaroubaceae
  • bioassays
  • cells
  • toxicite
  • toxicidad
  • test biologique
  • celulas
  • extracts
  • neoplasmas
  • neoplasms
  • malaisie