Evidence of anti-inflammatory effects of Passiflora edulis in an inflammation model  [2007]

Montanher, A.B. Zucolotto, S.M. Schenkel, E.P. Fröde, T.S.

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The popular medicine Passiflora edulis has been used as a sedative, tranquilizer, against cutaneous inflammatory diseases and intermittent fever. Most of the pharmacological investigations of Passiflora edulis have been addressed to its Central Nervous System activities, such as anxiolytic, anticonvulsant and sedative actions. Otherwise, there are few reports about the anti-inflammatory activity of the Passiflora species. The aim of this study was to investigate the mechanism of the anti-inflammatory effect of aqueous lyophilized extract obtained from leaves of Passiflora edulis var. flavicarpa Degener (Passifloraceae) in the mouse model of pleurisy induced by carrageenan (Cg), bradykinin, histamine or substance P, observing the effects upon leucocytes migration, myeloperoxidase (MPO), nitric oxide (NO) concentrations and tumor necrosis factor-alpha (TNFα) and interleukin-1 beta (IL-1β) levels. Results: Passiflora edulis (250 mg/kg) administered by intraperitoneal route (i.p.) inhibited the leukocyte, neutrophils, myeloperoxidase, nitric oxide, TNFα and IL-1β levels (P < 0.01) in the pleurisy induced by carrageenan. Passiflora edulis (250-500 mg/kg, i.p.) also inhibited total and differential leukocytes in the pleurisy induced by bradykinin, histamine or substance P (P < 0.05). Conclusion: Several mechanisms, including the inhibition of pro-inflammatory cytokines (TNFα, IL-1β), enzyme (myeloperoxidase) and mediators (bradykinin, histamine, substance P, nit
ric oxide) release and/or action, appear to account for Passiflora edulis's actions.

Other subjects

  • herbal medicines
  • bioassays
  • leaves
  • medicinal properties
  • plant extracts
  • chemical constituents of plants
  • traditional medicine
  • leukocytes
  • Passiflora edulis
  • medicinal plants
  • mice
  • anti-inflammatory activity

From the journal

Journal of ethnopharmacology

ISSN : 0378-8741


Other information

Language : English

Type : Journal Article

In AGRIS since : 2013

Volume : 109 issue 2

Start Page : 281

End Page : 288

All titles :

" Evidence of anti-inflammatory effects of Passiflora edulis in an inflammation model "