Immunomodulatory activities of edible beans and related constituents from soybean  [2007]

Cherng, J.M. Chiang, W. Chiang, L.C.

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To explore the health-modulating constituents of common edible beans, their immunomodulatory activity on human peripheral blood mononuclear cells (PBMC) was evaluated. Studies were conducted on lymphocyte transformation by BrdU immunoassay, secretion of interferon-gamma (IFN-γ) and interleukin 10 (IL-10) and elucidation of the responding cells by flow cytometry. The results at 20 μg/mL showed that genistein, phytic acid and syringic acid induced a Th1-predominant immune response because they significantly suppressed the secretion of IL-10 and augmented the IFN-γ production. The present study concludes that several non-nutritional ingredients of soybean such as flavonoids, plant acids and plant hormones most likely to be important in modulation of human immunity.

Other subjects

  • acids
  • immune response
  • protective effect
  • plant hormones
  • beans
  • immunomodulators
  • phytochemicals
  • Phaseolus
  • extraction
  • flavonoids
  • soybeans
  • mononuclear leukocytes

From the journal

Food chemistry

ISSN : 0308-8146