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Coincident Scrapie Infection and Nephritis Lead to Urinary Prion Excretion  [2005]

Seeger, Harald Heikenwalder, Mathias Zeller, Nicolas Kranich, Jan Schwarz, Petra Gaspert, Ariana Seifert, Burkhardt Miele, Gino Aguzzi, Adriano

Abstract
Prion infectivity is typically restricted to the central nervous and lymphatic systems of infected hosts, but chronic inflammation can expand the distribution of prions. We tested whether chronic inflammatory kidney disorders would trigger excretion of prion infectivity into urine. Urinary proteins from scrapie-infected mice with lymphocytic nephritis induced scrapie upon inoculation into noninfected indicator mice. Prionuria was found in presymptomatic scrapie-infected and in sick mice, whereas neither prionuria nor urinary PrP[superscript Sc] was detectable in prion-infected wild-type or PrP[superscript C]-overexpressing mice, or in nephritic mice inoculated with noninfectious brain. Thus, urine may provide a vector for horizontal prion transmission, and inflammation of excretory organs may influence prion spread.
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Other information

Language : English

Type : Journal Article

In AGRIS since : 2013

Volume : 310

Issue : 5746

Start Page : 324

End Page : 326

All titles :

" Coincident Scrapie Infection and Nephritis Lead to Urinary Prion Excretion "

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