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Cellular and biochemical effects induced by atrazine on blood of male Japanese quail (Coturnix japonica)  [2012]

Hussain, Riaz Mahmood, Fazal Khan, Ahrar Javed, Muhammad Tariq et al.

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Abstract
Atrazine a potent endocrine disruptor herbicide is broadly used to control rapidly growing unwanted weeds in various cereals crops which induce adverse effects both in mammalian and avian species. In present study 96 mature male Japanese quail (Coturnix japonica) were procured and randomly kept in eight groups (A to H) each having 12 birds. Atrazine was administered orally at 0, 10, 25, 50, 100, 250 and 500mg/kg body weight to all experimental groups. The mitomycin C at 2mg/kg body weight was given to the birds of group B which served as a positive control. From each group 4 birds were randomly selected and harvested at day 15, 30 and 45. A significant (P<0.05) decrease in serum total protein, serum albumin and serum testosterone values were recorded at day 45 in all treated groups. A significant increase in serum ALT and AST concentration was also recorded. Moreover, morphological alterations in nucleus of erythrocytes were also observed including blebbed nuclei, notched nuclei, lobed nuclei, vacuolated cells, binucleated cell, and cell with pear shaped and micronucleus. Overall, our results show that atrazine at higher doses induces significant serum biochemical alterations and changes in nucleus of erythrocytes.
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Other subjects

  • Coturnix
  • testosterone
  • Japanese quails
  • serum albumin
  • crops
  • grains
  • body weight
  • erythrocytes
  • oral administration
  • mammals
  • atrazine
  • mitomycin
  • alanine transaminase
  • adverse effects
  • weeds
  • aspartate transaminase
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Other information

Language : English

Type : Journal Article

In AGRIS since : 2014

Volume : 103

Issue : 1

Start Page : 38

End Page : 42

Publisher : Elsevier Inc.

All titles :

" Cellular and biochemical effects induced by atrazine on blood of male Japanese quail (Coturnix japonica) "