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Effects of α-linolenic acid supplementation in perilla oil on collagen-epinephrine closure time, activated partial thromboplastin time and Lp-PLA2 activity in non-diabetic and hypercholesterolaemic subjects  [2016]

Kim, Minkyung Dae Young Kwon Hye Jeong Yang Jong Ho Lee et al.

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Abstract
We examined whether α-linolenic acid (ALA) alters total-cholesterol and haemostatic factors and the relationship between such alterations and lipoprotein-associated phospholipase A2 (Lp-PLA2). Eighty-six non-diabetic, borderline-to-moderate hypercholesterolaemic human subjects were divided into two groups: ALA group and placebo group. After 8 weeks of treatment, the ALA group exhibited significant increases in plasma ALA, and reductions in total- and LDL-cholesterol. The ALA group showed significantly greater reductions in total- and LDL-cholesterol, ox-LDL, apo B and Lp-PLA2 activity and greater increases in plasma ALA, activated partial thromboplastin time (aPTT) and collagen-epinephrine (C-EPI) closure time (CT) than the placebo after adjusting for baseline levels. Independent and significant correlations between changes in C-EPI CT and plasma ALA, and between changes in aPTT and Lp-PLA2, were observed. In conclusion, ALA supplementation was associated with prolonged C-EPI CT and aPTT and decreased Lp-PLA2, which were mediated by decreasing LDL-cholesterol oxidation, thereby reducing substrate available for Lp-PLA2 (ClinicalTrials.gov:NCT02609295; http://www.clinicaltrials.gov).
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Other subjects

  • α-linolenic acid
  • PT
  • phospholipase A2
  • PAF-AH
  • thromboplastin
  • apo B
  • hypercholesterolemia
  • BP
  • Lp-PLA2
  • placebos
  • SE
  • perilla oil
  • Perilla oil
  • PFA-100
  • aPTT
  • alpha-linolenic acid
  • oxidation
  • ox-LDL
  • GC-MS
  • C-EPI
  • CT
  • C-EPI CT
  • FAME
  • ALA
  • humans
  • low density lipoprotein cholesterol
  • MCT

From the journal

Journal of functional foods

ISSN : 1756-4646

Other information

Language : English

Type : Journal Article

In AGRIS since : 2017

Volume : 23

Start Page : 95

End Page : 104

Publisher : Elsevier Ltd

All titles :

" Effects of α-linolenic acid supplementation in perilla oil on collagen-epinephrine closure time, activated partial thromboplastin time and Lp-PLA2 activity in non-diabetic and hypercholesterolaemic subjects "