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Effects of probiotics supplementation on macrophage migration inhibitory factor and clinical laboratory feature of polycystic ovary syndrome  [2017]

Nearmeen M. Rashad Amal S. El-Shal et al.

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Polycystic ovary syndrome (PCOS) is a set of reproductive and metabolic symptoms associated with an imbalance of reproductive hormones in women. Macrophage migration inhibitory factor (MIF) is an inflammatory adipcytokine associated with metabolic disorders. Probiotics probably has influence on metabolic and inflammatory conditions. We aimed for the first time to evaluate the impact of probiotic supplementation on MIF values, clinical and laboratory feature of PCOS, further we aimed to explore the power of MIF for diagnosis PCOS.Sixty women diagnosed with PCOS were selected in this single- blinded clinical trial. Using balanced block random sampling, 40 healthy control women .Participants received probiotic supplements for 12-week. Clinical and laboratory measures were evaluated at baseline and after 12 weeks of intervention. High sensitivity C-reactive protein(hs-CRP) and MIF levels were assessed using an enzyme-linked immunosorbent assay (ELISA).Probiotic supplementation improved clinical, hormonal and inflammatory markers in women with PCOS. Additionally, in PCOS group, logistic regression analysis revealed that MIF and HOMA-IR were independent predictors of probiotic response with odds ratios of 1.641 and 0.335, respectively .Regarding inflammatory markers, hs-CRP and MIF, its value increased in PCOS group compared to healthy group. Receiver operating characteristic curve (ROC) analysis revealed that, AUC for the MIF was 0.981 (95% CI = 0.902–0.898)
with sensitivity = 90.2%, specificity = 89.8% and the cutoff values (19.7). Interestingly, the power of MIF was more sensitive and specific than hs-CRP in diagnosis of PCOS. Thus MIF could be a useful diagnostic inflammatory biomarker discriminate PCOS from healthy controls. Moreover, in PCOS group stepwise multiple linear regression analysis, detected that, HOMA-IR, neutrophil count, hs-CRP and FMI were main predictors of MIF levels among other clinical and laboratory biomarkersRegarding the effects of probiotic supplementation on inflammatory and metabolic disorders; our novel findings explored a favorable effect of probiotic supplementation on inflammatory biomarkers; clinical, laboratory features of PCOS, and MIF levels. Furthermore, probiotic could be used for treatment of PCOS and its associated morbidity.

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Journal of functional foods

ISSN : 1756-4646