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impact of obesity on neurodegenerative diseases  [2017]

Janaína Niero Mazon Aline Haas de Mello et al.

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Abstract
Neurodegenerative diseases are a growing health concern. The increasing incidences of these disorders have a great impact on the patients' quality of life. Although the mechanisms of neurodegenerative diseases are still far from being clarified, several studies look for new discoveries about their pathophysiology and prevention. Furthermore, evidence has shown a strong correlation between obesity and the development of Alzheimer's disease (AD) and Parkinson's disease (PD). Metabolic changes caused by overweight are related to damage to the central nervous system (CNS), which can lead to neural death, either by apoptosis or cell necrosis, as well as alter the synaptic plasticity of the neuron. This review aims to show the association between neurodegenerative diseases, focusing on AD and PD, and metabolic alterations.
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Other subjects

  • Obesity
  • Parkinson's disease
  • death
  • Neurodegenerative diseases
  • Alzheimer disease
  • patients
  • Parkinson disease
  • apoptosis
  • neurons
  • central nervous system
  • necrosis
  • pathophysiology
  • quality of life
  • Alzheimer's disease
  • obesity
  • neuroplasticity

From the journal

Life sciences

ISSN : 0024-3205

Other information

Language : English

Type : Journal Article

In AGRIS since : 2017

Volume : 182 (13

Extent : 22-28

Publisher : Elsevier Inc.

All titles :

" impact of obesity on neurodegenerative diseases "