Written Paper

Reassessment of the nutritional function of phytic acid, with special reference to myo-inositol function  [2005]

Okazaki, Y.(Hiroshima Univ. (Japan)) Katayama, T.

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Phytic acid (myo-inositol hexaphosphoric acid, IP6) has the ability to chelate minerals because of its reactive phosphate groups attached to the inositol ring. Most published reports on phytic acid have focused on possible decreased mineral absorption due to its ability to chelate divalent cations. On the other hand, a number of studies have shown that myo -inositol functions as a lipotropic factor. We have shown that, in addition to dietary myo-inositol, dietary phytic acid reduces excessive hepatic triglyceride. Many studies by other groups have also shown that phytic acid and myo-inositol have anticancer activity. Some researchers have recently demonstrated that phytic acid is present as an intracellular molecule in mammalian cells, and has a number of physiological functions such as vesicle trafficking and cell signaling. These properties suggest that phytic acid might function as a vitamin-like substance. We should therefore consider that phytic acid could be involved in various biological roles.


Journal of Japanese Society of Nutrition and Food Science (Japan)

ISSN : 0287-3516