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Paper

Written Paper

A tyrosinase inhibitor, daedalin A, from mycelial culture of Daedalea dickinsii  [2007]

Morimura, K.(Shinshu Univ., Minami-minowa, Nagano (Japan)) Yamazaki, C. Hattori, Y. Makabe, H. et al.

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A chromene-type compound, daedalin A (1), was isolated from mycelial culture broth of Daedalea dickinsii. Based on spectroscopic data, the structure of 1 was found to be (2R)-6-hydroxy-2-hydroxymethyl-2-methyl-2H-chromene. Daedalin A (1) strongly inhibited the activity of tyrosinase (ICsub(50): 194 microM). In addition, 1 also showed 1,1-diphenyl-2-picrylhydrazyl scavenging activity (ICsub(50): 16.9 microM) and superoxide anion scavenging activity (ICsub(50): 28.5 microM).

Publicación

Bioscience, Biotechnology and Biochemistry (Japan)

ISSN : 0916-8451

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