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Written Paper

Anthelmintic activity of Fumaria parviflora (Fumariaceae) against gastrointestinal nematodes of sheep  [2009]

Al-Shaibani, I.R.M. (University of Thamar (Yemen). Dept. of Veterinary Parasitology) Phulan, M.S. (Sindh Agriculture Univ., Tandojam (Pakistan). Dept. of Veterinary Parasitology) Shiekh, M. (Sindh Agriculture Univ., Tandojam (Pakistan). Dept. of Horticulture)

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The anthelmintic activity of Fumaria parviflora was evaluated against the gastrointestinal nematodes of sheep through egg hatch and larval development tests in vitro and faecal egg counts reduction test in vivo. In vitro studies revealed that aqueous and ethanolic extracts at the concentration of 3.12, 6.3, 12.5, 25.0 and 50.0 mg/mL exhibited ovicidal and larvicidal effects (P less than 0.05) against the eggs and larvae of gastrointestinal nematodes. The highest effective dose (ED50) value of F. parviflora extract was recorded on the eggs of Chabertia ovina (14.45 mg/mL) with aqueous extract; whereas, the lower value was recorded on the eggs of Haemonchus contortus (9.12 mg/mL) with ethanolic extract. Similarly, the higher LC50 value of F. paniflora extracts was recorded against the larvae of Strongyloides papillosus (16.60) and the lower value against the larvae of H. contortus (10.23 mg/mL) with aqueous and ethanolic extracts respectively. I n vivo studies revealed that experimental animal groups treated with the doses of 200 mg/kg of either aqueous or ethanolic extracts of F. parviflora exhibited higher (p less than 0.05) reduction rate on faecal egg counts (FEC) as compared to un-treated groups (negative control). The highest reduction rate on FEC of treated animal groups recorded was 77.6 and 70.05% with ethanolic and aqueous extracts, respectively at the dose of 200 mg/kg on the day 14 post treatment, whereas at the treatment doses of 50 and 100 mg/
kg, the reduction rate ranged between 3.79 to 61.45% from day 3 to 14 post treatment. The current study showed that F. parviflora whole plant extracts possess anthelmintic activity, thus justifying their use in traditional veterinary practices.

Publicación

International Journal of Agriculture and Biology (Pakistan)

ISSN : 1560-8530

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