The Relationship between Vascular Endothelial Growth Factor -634G greater than C Polymorphism and Ovarian, Cervical and Endometrial Cancers

Konac, Ece (Gazi University, Besevler, Ankara, Turkey); Onen, H. Ilke (Gazi University, Besevler, Ankara, Turkey); Metindir, Jale (Ankara Oncology Education and Research Hospital, Demetevler, Ankara, Turkey); Almayanlar, Ebru (Gazi University, Besevler, Ankara, Turkey); Biri, Aydan Asyali (Gazi University, Besevler, Ankara, Turkey); Ekmekci, Abdullah (Gazi University, Besevler, Ankara, Turkey), E-mail: ecem@gazi.edu.tr

The Relationship between Vascular Endothelial Growth Factor -634G greater than C Polymorphism and Ovarian, Cervical and Endometrial Cancers [2006]

Konac, Ece (Gazi University, Besevler, Ankara, Turkey) Onen, H. Ilke (Gazi University, Besevler, Ankara, Turkey) Metindir, Jale (Ankara Oncology Education and Research Hospital, Demetevler, Ankara, Turkey) Almayanlar, Ebru (Gazi University, Besevler, Ankara, Turkey) et al.

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Résumé

Tumor growth and metastasis require the formation of new blood vessels, a process known as angiogenesis. One of the most important regulators employed in this process is the vascular endothelial growth factor (VEGF). The phenotypic effects of single nucleotide polymorphisms (SNPs) are based on direct genetic effects, gene-gene and gene-environment interactions. DNA sequence variations in VEGF gene might yield changes both in the production outcomes and in the activities of the gene.