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Antibacterial Activity of Sanguisorba officinalis against Helicobacter pylori  [2010]

Lee, H.A., Center for Animal Resources Development, Wonkwang University, Iksan, Republic of Korea Hong, S.H., Center for Animal Resources Development, Wonkwang University, Iksan, Republic of Korea Oh, H.G., Huvet Co. Ltd., Iksan, Republic of Korea Park, S.H., Korea DNA Valley Co. Ltd., Iksan, Republic of Korea et al.

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摘要
In this study, a medicinal herbal plant, Sanguisorba officinalis, was examined and screened for anti-Helicobacter pylori (H. pylori) activity. Seventy percent ethanol was used for herbal extraction. For anti-H. pylori activity screening, inhibitory zone tests as an in vitro assay and in vivo study using a Mongolian gerbil (Meriones unguiculatus) model were performed. Also, the safety of herbal compounds was evaluated by animal study. As a result of inhibitory zone test, Sanguisorba officinalis extract demonstrated strong anti-H. pylori activities. Also, as results of in vivo animal studies, Sanguisorba officinalis extract demonstrated strong therapeutic effects against H. pylori infection according to the criteria of histological examination and rapid urease test. As results of the safety study, after 28 days treatment of the Sanguisorba officinalis extract, the animals were not detected any grossly and histological changes. These results demonstrate that it can be successfully cured against H. pylori infection and protected from H. pylori-induced pathology with Sanguisorba officinalis extract. It could be a promising candidate herb treatment for patients with gastric complaints including gastric ulcer caused by H. pylori.
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其它题目

  • Sanguisorba officinalis
  • antibacterial activity
  • helicobacter pylori
  • therapy
  • therapeutique
  • herbaceous plants
  • plante herbacee
  • terapia
  • plantas herbaceas

学术期刊

Laboratory Animal Research

ISSN : 1738-6055

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其他信息

语言 : Korean

类型 : Directory

In AGRIS since : 2013

: 26

: 3

Start Page : 257

End Page : 263

所有题名 :

" Antibacterial Activity of Sanguisorba officinalis against Helicobacter pylori "