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Synthesis of Dibenzoxepine Lactams via a Cu-Catalyzed One-Pot Etherification/Aldol Condensation Cascade Reaction: Application toward the Total Synthesis of Aristoyagonine  [2013]

Lim, Hye Sun Choi, Young Lok Heo, Jung-Nyoung

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摘要
A general synthesis of dibenzoxepine lactams has been developed using a one-pot Cu-catalyzed etherification/aldol condensation cascade reaction. The reaction of 4-hydroxyisoindolin-1-one with a wide range of 2-bromobenzaldehydes in the presence of a copper catalyst provided various aristoyagonine derivatives in good yields.
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其它题目

  • lactams
  • catalysts
  • condensation reactions
  • copper
  • chemical structure

学术期刊

Organic letters

ISSN : 1523-7052