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Selenium (Se) deficiency is associated with the occurrence of many diseases. However, excessive Se supplementation, especially with inorganic Se, can result in toxicity. Selenoproteins are the major forms of Se in vivo to exert its biological function. Expression of those selenoproteins, especially with the application of a newly developed system, is thus very important for studying the mechan ...

SUBJECT: chlamydomonas reinhardtii (c. reinhardtii); 15-kda selenoprotein (sep15); selenocysteine insertion sequence (secis); alga; selenium (se)

POSTED TO: Nutrients

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Obesity, insulin resistance, hypertension and fatty liver, together termed metabolic syndrome, are key risk factors for cardiovascular disease. Chronic feeding of a diet high in saturated fats and simple sugars, such as fructose and glucose, induces these changes in rats. Naturally occurring compounds could be a cost-effective intervention to reverse these changes. Flavonoids are ubiquitous se ...

SUBJECT: inflammation; mitochondria; naringin; hypertension; obesity

POSTED TO: Nutrients

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Cow’s milk allergy (CMA) continues to be a growing health concern for infants living in Western countries. The long-term prognosis for the majority of affected infants is good, with about 80% naturally acquiring tolerance by the age of four years. However, recent studies suggest that the natural history of CMA is changing, with an increasing persistence until later ages. The pathogenesis of CM ...

SUBJECT: tolerance acquisition; immune system; intestinal microflora; food allergy; probiotics

POSTED TO: Nutrients

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Extracts, subfractions, isolated anthocyanins and isolated procyanidins B2, B5 and C1 from the berries and bark of Aronia melanocarpa were investigated for their antioxidant and enzyme inhibitory activities. Four different bioassays were used, namely scavenging of the diphenylpicrylhydrazyl (DPPH) radical, inhibition of 15-lipoxygenase (15-LO), inhibition of xanthine oxidase (XO) and inhibitio ...

SUBJECT: α-glucosidase; dpph; anthocyanins; aronia melanocarpa; procyanidins

POSTED TO: Nutrients

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Short bowel syndrome (SBS) is a cause of significant morbidity and mortality in children. Probiotics, due to their beneficial effects on the gastrointestinal tract (e.g., improving gut barrier function, motility, facilitation of intestinal adaptation and decreasing pathogen load and inflammation) may have a therapeutic role in the management of SBS. To conduct a systematic review of the curren ...

SUBJECT: infants; children; review; short bowel syndrome; probiotics

POSTED TO: Nutrients

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Enshi is a high selenium (Se) region in Hubei, China, where human selenosis was observed between 1958 and 1963. This study investigated the daily dietary Se intake of residents in Shadi, a town located 72 km northeast of Enshi City, to assess the risk of human selenosis in the high Se area. Foods consumed typically by the local residents and their hair samples were analyzed for total Se concen ...

SUBJECT: selenosis; hair; selenium; enshi; daily dietary intake

POSTED TO: Nutrients

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Previous studies have revealed that diabetic patients have a decline in immunity and an increased risk of infections, and this may be associated with poor micronutrient status. The aim of this study was to measure the effect of dietary supplements on risk of infection in patients with type 2 diabetes mellitus. One hundred patients with type 2 diabetes mellitus were randomly assigned to receive ...

SUBJECT: dietary supplement; type 2 diabetes mellitus; risk of infection; antioxidant vitamins; b-group vitamins

POSTED TO: Nutrients

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Selenium for the Prevention of Cutaneous Melanoma

Pamela B. Cassidy et al. [2013-03-07]

The role of selenium (Se) supplementation in cancer prevention is controversial; effects often depend on the nutritional status of the subject and on the chemical form in which Se is provided. We used a combination of in vitro and in vivo models to study two unique therapeutic windows for intervention in the process of cutaneous melanomagenisis, and to examine the utility of two different chem ...

SUBJECT: selenium; methylseleninic acid; melanoma; selenomethionine; hgf mouse

POSTED TO: Nutrients

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The objective of this project was to investigate the relationships between total and regional distribution of body fat and tissue lutein (L) and zeaxanthin (Z) status. Healthy men and women (N = 100; average age: 22.5 year, average BMI: 23.4 kg/m2) were evaluated. Total body and regional fat mass were assessed by dual-energy X-ray absorptiometry (Hologic Delphi A). Serum LZ was measured using ...

SUBJECT: adiposity; lutein; body fat; zeaxanthin

POSTED TO: Nutrients

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Selenium is an essential trace mineral of fundamental importance to human health. Much of its beneficial influence is attributed to its presence within selenoproteins, a group of proteins containing the rare amino acid selenocysteine. There are 25 known human selenoproteins including glutathione peroxidases, thioredoxin reductases and selenoproteins. Selenoprotein S (SEPS1) is an endoplasmic r ...

SUBJECT: selenoprotein s; selenium; alpha-1 antitrypsin deficiency; chronic obstructive pulmonary disease

POSTED TO: Nutrients

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