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Journal Article

Journal Article

Immunostimulating and Anticancer Activities of Hot-water Extracts from Acanthopanax senticosus and Glycyrrhiza uralensis  [2008]

Hwang, J.H. (Chungju National University, Jeungpyeong, Republic of Korea); Suh, H.J. (Korea University, Seoul, Republic of Korea); Yu, K.W. (Chungju National University, Jeungpyeong, Republic of Korea), E-mail: kwyu@cjnu.ac.kr;

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When 10 kinds of herbal medicines were fractionated into hexane, MeOH, cold-water, and hot-water extracts, hot-water extracts from Acanthopanax senticosus (AS), Glycyrrhiza uralensis (GU), Cichorium intybus (CI), and Polygonatum odoratum (PO) showed the potent intestinal immune system modulating activity (1.72-, 1.62-, 1.60-, and 1.53-fold of control at 100 ㎍/mL, respectively). Especially, hot-water extracts from AS (215% compared with the control) and GU (187%) also had macrophages stimulating activity and mitogenic activity of splenocytes (7.1- and 6.5-fold) at 100 ㎍/mL. In addition, the effects of hot-water extracts from herbal medicines on anticancer activities were studied in mice. Hot-water extracts from AS and GU enhanced cytotoxicity of natural killer cell against cancer cell, Yac-1 (37 and 34% cytotoxicity) at E/T ratio 100:1, and colon 26-M3.1 cancer cell lines had significantly inhibited (82.1 and 75.2%) in experimental lung metastasis. These results suggest that hot-water extracts from A. senticosus and G. uralensis call be used as biological response modifiers to stimulate immune system and inhibit tumor.
From the journal
Food Science and Biotechnology
ISSN : 1226-7708

Bibliographic information

Language:
English
Type:
Directory
In AGRIS since:
2009
Volume:
17
Issue:
6
Start Page:
1185
End Page:
1190
All titles:
"Immunostimulating and Anticancer Activities of Hot-water Extracts from Acanthopanax senticosus and Glycyrrhiza uralensis"@eng
Other:
"Summary(En)"
"2 tables"
"3ill., 33 ref."
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Bibliographic information

Language:
English
Type:
Directory
In AGRIS since:
2009
Volume:
17
Issue:
6
Start Page:
1185
End Page:
1190
All titles:
"Immunostimulating and Anticancer Activities of Hot-water Extracts from Acanthopanax senticosus and Glycyrrhiza uralensis"@eng
Other:
"Summary(En)"
"2 tables"
"3ill., 33 ref."