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Journal Article

Journal Article

Ameliorating Effects of Herbal Ethanol Extract from Gynostemma pentaphyllum on Chronic Stress-Induced Anxiety in Mice  [2011]

Choi, H.S., Chungbuk National University, Cheongju, Republic of Korea; Shin, K.S., Chungbuk National University, Cheongju, Republic of Korea; Choi, S.O., Chungbuk National University, Cheongju, Republic of Korea; Kim, S.H., Kyung Hee University, Yongin, Republic of Korea; et al.

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The effects of herbal ethanol extract from Gynostemma pentaphyllum (GP extract) on chronic stress-induced anxiety in mice were investigated. The animals were treated with GP extracts (50 and 100 mg/kg/day, p.o.) for 21 days before exposure to electric footshock (EF; duration and interval 10 sec for 3 min, 2 mA) for chronic stress once a day. The ambulatory locomotor activity was reduced by chronic EF stress and it was recovered by 12.9-15.1% in GP extract-treated groups. The grip strength was also significantly decreased by chronic EF stress, however, the EF-stressed groups treated with GP extract increased grip strength from 13.9% to 56.8% compared to EF-stressed groups. In addition, the serum levels of corticosterone were significantly elevated by chronic EF stress to 197% of the control levels, which was reduced to 73.1% by treatment with GP extract (100 mg/kg). In contrast, the brain levels of dopamine and serotonin were reduced to 67.6% and 63.1% by chronic EF stress, which was recovered to 90% of the control levels by treatment with GP extract. These results indicate that GP extract shows the ameliorating effects on chronic EF stress-induced anxiety in mice and it can be developed as the promising anti-anxiety agent.

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Bibliographic information

Language:
Korean
Type:
Directory
In AGRIS since:
2013
Volume:
42
Issue:
1
Start Page:
32
End Page:
37
All titles:
" Ameliorating Effects of Herbal Ethanol Extract from Gynostemma pentaphyllum on Chronic Stress-Induced Anxiety in Mice "
" 돌외 에탄올 추출물 엑스의 만성 스트레스-유도 불안작용에 대한 개선작용 "
Other:
" Summary(En) "
" 5ill., 29 ref. "

From the journal

Korean Journal of Pharmacognosy

ISSN : 0253-3073