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Hypoglycemic and repaired DNA damage effects of flavonoids of Ipomoea batatas leaves on type Ⅱ diabetes mellitus mice model  [2012]

Li Fenglin, Yanshan University, Qinhuangdao, Hebei (China), College of Enviroment and Chemical Engineering; Li Qingwang, Yanshan University, Qinhuangdao, Hebei (China), College of Enviroment and Chemical Engineering; Geng Guoxia, Northwest Agriculture and Forestry University, Yangling (China), College of Animal Science and Technology;

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Hypoglycemic effect of flavonoids of Ipomoea batatas leaves (FIBL) and its effect on the repair of DNA damage of diabetes mellitus were studied. The high sugar and high fat diet and streptozotocin (STZ) induced typeⅡdiabetes mellitus (non-insulin dependent diabetes mellitus, NIDDM) mice model were used, and then divided into model control group, FIBL low-dose group, FIBL high-dose group and rosiglitazone group. Some normal mice were taken as normal control group. Mice of model control group and normal control group were daily fed 0.2 mL dH2O, respectively; mice of FIBL low-dose group and high-dose group were daily fed 75 and 150 mg/kg FIBL respectively and mice of RT were daily fed 3 mg/kg rosiglitazone, all for 28 d continuously. Observation of animals in general was carried out, and blood of tail vein was collected to measure glucose after 0, 7, 14, 21, 28 d. On 29 d, blood of heads was collected to measure lipids and lymphocytes were separated, and then single cell gel electrophoresis (SCGE) was used to test DNA damage. After the animal models had been successfully set up, NIDDM mice showed some symptoms, including polydipsia, polyuria, polyphagia and a certain degree of insulin resistance. Treatment results of FIBL showed that FIBL could control NIDDM mice from increasing body weight, decreasing blood glucose and blood lipid levels. FIBL could repair DNA damage of NIDDM mice. Flavonoids of Ipomoea batatas leaves can improve the symptoms of high blood s
ugar and lipid metabolism, can treat and delay the occurence of NIDDM complication.
(Revue
Journal of Northwest Agriculture and Forestry University
ISSN : 1671-9387

Information bibliographique

Langue:
zho
Type:
Journal Article
Sur AGRIS depuis:
2013
Volume:
40
Numéro:
5
Page initiale:
5
Page finale:
10
Tous les titres:
"Hypoglycemic and repaired DNA damage effects of flavonoids of Ipomoea batatas leaves on type Ⅱ diabetes mellitus mice model"@eng
"甘薯叶黄酮对Ⅱ型糖尿病模型小鼠的降糖及DNA损伤修复作用"@zho
Autre:
"Resume(Zh,En)"
"18 ref."
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Information bibliographique

Langue:
zho
Type:
Journal Article
Sur AGRIS depuis:
2013
Volume:
40
Numéro:
5
Page initiale:
5
Page finale:
10
Tous les titres:
"Hypoglycemic and repaired DNA damage effects of flavonoids of Ipomoea batatas leaves on type Ⅱ diabetes mellitus mice model"@eng
"甘薯叶黄酮对Ⅱ型糖尿病模型小鼠的降糖及DNA损伤修复作用"@zho
Autre:
"Resume(Zh,En)"
"18 ref."