The effect of synthetic analogs of brassinosteroids (brassinolid, epibrassinolid, homobrassinolid) on the growth, the stem firmness, and productivity of the spring barley cultivar Nosovsky 9 and the perennial wheat cultivar Zernokormovaya 169 has been studied in greenhouse and field experiments. The aim of experiments was to develop principally new approaches to the increase of cereals' resistance to the lodging. It has been shown that brassinosteroids possessed a high physiological activity, expressed in the induced activity of alpha-amylase in the barley endosperm, the increase of the grain weight per ear, the 1000-gain weight, and the yield. Under the spraying with synthetic analogs (10** (-5) mg/l) during the flowering, the barley stem diameter and firmness also increased, which conditioned an improved resistance to the lodging