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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

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Aminated β-cyclodextrin-grafted Fe₃O₄-loaded gambogic acid magnetic nanoparticles: preparation, characterization, and biological evaluation  [2019]

Fang, Wei; Dai, Ya Ji; Wang, Ting; Gao, Hai Tao; et al.

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Based on aminated β-cyclodextrin (6-NH₂-β-CD)-grafted Fe₃O₄ and gambogic acid (GA) clathrate complexes, a nanoparticle delivery system was developed with the aim to achieve low irritation, strong targeting, and high bioavailability of a gambogic acid magnetic nanopreparation. 6-NH₂-β-CD grafted onto Fe₃O₄ MNPs was demonstrated by high-resolution transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, zeta potential, and magnetic measurements. The average particle size of the Fe₃O₄@NH₂-β-CD MNPs was 147.4 ± 0.28 nm and the PDI was 0.072 ± 0.013. The encapsulation efficiency, drug loading, zeta potential, and magnetic saturation values of the Fe₃O₄@NH₂-β-CD MNPs were 85.71 ± 3.47%, 4.63 ± 0.04%, −29.3 ± 0.42 mV, and 46.68 emu g⁻¹, respectively. Compared with free GA, the in vitro release profile of GA from Fe₃O₄@NH₂-β-CD MNPs was characterized by two phases: an initial fast release and a delayed-release phase. The Fe₃O₄@NH₂-β-CD MNPs displayed continuously increased cytotoxicity against HL-60 and HepG2 cell lines in 24 h, whereas the carrier Fe₃O₄@NH₂-β-CD MNPs showed almost no cytotoxicity, indicating that the release of GA from the nanoparticles had a sustained profile and Fe₃O₄@NH₂-β-CD MNPs as a tumor tissue-targeted drug delivery system have great potential. Besides, blood vessel irritation tests suggested that the vascular irritation could be reduced by the use of Fe₃O₄@NH₂-β-CD MNPs encapsulation for GA. The t₁/₂
and the AUC of the Fe₃O₄@NH₂-β-CD@GA MNPs were found to be higher than those for the GA solution by approximately 2.71-fold and 2.42-fold in a pharmacokinetic study, respectively. The better biocompatibility and the combined properties of specific targeting and complexation ability with hydrophobic drugs make the Fe₃O₄@NH₂-β-CD MNPs an exciting prospect for the targeted delivery of GA.
来自期刊
RSC advances
ISSN : 2046-2069

书目信息

语言:
English
类型:
Journal Article
自何时收录于AGRIS:
2019
卷:
9
期:
47
范围:
27136-27146
出版者:
The Royal Society of Chemistry
所有题名:
"Aminated β-cyclodextrin-grafted Fe₃O₄-loaded gambogic acid magnetic nanoparticles: preparation, characterization, and biological evaluation"@eng
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书目信息

语言:
English
类型:
Journal Article
自何时收录于AGRIS:
2019
卷:
9
期:
47
范围:
27136-27146
出版者:
The Royal Society of Chemistry
所有题名:
"Aminated β-cyclodextrin-grafted Fe₃O₄-loaded gambogic acid magnetic nanoparticles: preparation, characterization, and biological evaluation"@eng