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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

فعّال (مزود البيانات قام بتقديم البيانات الوصفية السنة الماضية)
Journal Article

مقال مجلة

Medicinal herbs Oenanthe javanica (Blume) DC., Casuarina equisetifolia L. and Sorghum bicolor (L.) Moench protect human cells from MPP+ damage via inducing FBXO7 expression  [2016]

Chen, Chiung-Mei; Cheng-Yu Lee; Chih-Ying Chao; Chi-Mei Lee; et al.

استعراض النص الكامل

The F-box protein 7 (FBXO7) mutations have been identified in families with early-onset parkinsonism and pyramidal tract signs, and designated as PARK15. In addition, FBXO7 mutations were found in typical and young onset Parkinson's disease (PD). Evidence has also shown that FBXO7 plays an important role in the development of dopaminergic neurons and increased stability and overexpression of FBXO7 may be beneficial to PD.We screened extracts of medicinal herbs to enhance FBXO7 expression for neuroprotection in MPP+-treated cells.Promoter reporter assay in HEK-293 cells was used to examine the cis/trans elements controlling FBXO7 expression and to screen extracts of medicinal herbs enhancing FBXO7 expression. MTT assay was performed to assess cell viability of MPP+-treated HEK-293/SH-SY5Y cells. In addition, proteasome activity, mitochondrial membrane potential and FBXO7/TRAF2/GATA2 protein expression were evaluated.We demonstrated that −202–−57 region of the FBXO7 promoter is likely to contain sequences that are bound by positive trans protein factors to activate FBXO7 expression and GATA2 is the main trans protein factor enhancing FBXO7 expression. Extracts of medicinal herbs Oenanthe javanica (Blume) DC. (Umbelliferae), Casuarina equisetifolia L. (Casuarinaceae), and Sorghum bicolor (L.) Moench (Gramineae) improved cell viability of both MPP+-treated HEK-293 and SH-SY5Y cells, rescued proteasome activity in MPP+-treated HEK-293 cells, and restored
mitochondrial membrane potential in MPP+-treated SH-SY5Y cells. These protection effects of herbal extracts are acting through enhancing FBXO7 and decreasing TRAF2 expression, which is probably mediated by GATA2 induction.Collectively, our study provides new targets, FBXO7 and its regulator GATA2, for the development of potential treatments of PD.
المجلة
Phytomedicine
الرقم التسلسلي المعياري الدولي (ردمد) : 0944-7113

معلومات ببليوغرافية

اللغة:
English
النوع:
Journal Article
في أجريس منذ:
2017
المجلد:
15 v. 23
صفحة البداية:
1422
صفحة النهاية:
1433
الناشر:
Elsevier GmbH
جميع العناوين:
"Medicinal herbs Oenanthe javanica (Blume) DC., Casuarina equisetifolia L. and Sorghum bicolor (L.) Moench protect human cells from MPP+ damage via inducing FBXO7 expression"@eng
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معلومات ببليوغرافية

اللغة:
English
النوع:
Journal Article
في أجريس منذ:
2017
المجلد:
15 v. 23
صفحة البداية:
1422
صفحة النهاية:
1433
الناشر:
Elsevier GmbH
جميع العناوين:
"Medicinal herbs Oenanthe javanica (Blume) DC., Casuarina equisetifolia L. and Sorghum bicolor (L.) Moench protect human cells from MPP+ damage via inducing FBXO7 expression"@eng