The article shows the influence of mineral and organic fertilizer norms on gray–brown soils and changes in the nutritional regime in winter wheat soils under irrigation in the Ganja–Gazakh region. It was found that the application of mineral and organic fertilizers for winter wheat in gray–brown soils significantly affected the change in the nutrient regime of the soil, significantly increasing the amount of nutrients easily absorbed by plants in the plowed and subsoil layers of the soil, as compared to the control (unfertilized) option, effective fertility increased, which in turn had a significant impact on productivity. At the end of the growing season, depending on the norm of mineral fertilizers in the soil layer 0–60 cm, ammonia nitrogen is 13.1–14.1, nitrate nitrogen is 7.2–7.4, mobile phosphorus is 7.0–8.0 and exchangeable potassium — 15.6–19.2 mg/kg, depending on the rate of organic fertilizers at the end of the growing season, ammonia nitrogen 12.6-–13.7, nitrate nitrogen 5.3–5.7, mobile phosphorus 6.2–6.6 and metabolic potassium while it increased by 20.4–21.2 mg/kg.