Fifteen healthy SD female rats and fifteen healthy male rats weighting about 100 g were randomly distributed into three groups.The transgenic milk group was infused with transgenic human lactoferrin gene（hLF）goats′ milk 1 mL（protein concentration at 0.93 g・mL-1）,directly into the gastric two times a day;the normal milk group with normal goats′ milk（protein concentration at 0.93 g・mL-1）,and the physiological saline group with sterile pyrogen-free physiological saline at the same quantity.Three groups were provided a standard rodent chow and an ad libitum supply of water.After 15 days of infusing,all the rats were killed by collecting living body blood in venous of neck.The result indicated that the average daily gain of the female and male rats which were infused with transgenic hLF goats′ milk increased in evidence compared to the physiological saline group（P0.01）and the normal milk group（P〈0.05）.However,there were no difference between the normal milk group and the physiological saline group.And the other measurements and biochemical examination of the transgenic milk group and the normal milk group didn′t change significantly compared to the physiological saline group（P〉0.05）,moreover,no obvious change were observed between the transgenic and normal milk group.Overall,the result of the present study demonstrates that transgenic hLF goats′ milk can enhance rats growth performance but has no effect on its metabolism by infusing administration in short time.