Article de revue
The Protective Effect of Chlorophyll a Against Oxidative Stress and Inflammatory Processes in LPS-stimulated Macrophages [2007]
Park, J.Y. (Inje University, Gimhae, Republic of Korea); Park, C.M. (Inje University, Gimhae, Republic of Korea); Kim, J.J. (Inje University, Gimhae, Republic of Korea); Noh, K.H. (Inje University, Gimhae, Republic of Korea); et al.
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This study was designed to investigate the suppressive effect of chlorophyll a on nitric oxide (NO) production and intracellular oxidative stress. In addition, chlorophyll a regulation of nuclear factor (NF) κB activation and inducible NO synthase (iNOS) expression were explored as potential mechanisms of NO suppression in a lipopolysaccharide (LPS)-stimulated macrophage cell line. RAW 264.7 murine macrophages were preincubated with various concentrations (0-10 ㎍/mL) of chlorophyll a and stimulated with LPS to induce oxidative stress and inflammatory response.
