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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

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Journal Article

期刊文章

Decursin in Angelica gigas Nakai (AGN) Enhances Doxorubicin Chemosensitivity in NCI/ADR‐RES Ovarian Cancer Cells via Inhibition of P‐glycoprotein Expression  [2016]

Hyeong Sim; Choi; Sung‐Gook; Cho; et al.

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Angelica gigas Nakai (AGN, Korean Dang‐gui) is traditionally used for the treatment of various diseases including cancer. Here, we investigated multidrug‐resistant phenotype‐reversal activities of AGN and its compounds (decursin, ferulic acid, and nodakenin) in doxorubicin‐resistant NCI/ADR‐RES ovarian cancer cells. Our results showed that a combination of doxorubicin with either AGN or decursin inhibited a proliferation of NCI/ADR‐RES cells. These combinations increased the number of cells at sub‐G1 phase when cells were stained with Annexin V‐fluorescein isothiocyanate. We also found that these combinations activated caspase‐9, caspase‐8, and caspase‐3 and increased cleaved PARP level. Moreover, an inhibition of P‐glycoprotein expression by either AGN or decursin resulted in a reduction of its activity in NCI/ADR‐RES cells. Therefore, our data demonstrate that decursin in AGN inhibits doxorubicin‐resistant ovarian cancer cell proliferation and induces apoptosis in the presence of doxorubicin via blocking P‐glycoprotein expression. Therefore, AGN would be a potentially novel treatment option for multidrug‐resistant tumors by sensitizing to anticancer agents. Copyright © 2016 John Wiley & Sons, Ltd.
来自期刊
Phytotherapy research
ISSN : 0951-418X

书目信息

语言:
English
类型:
Journal Article
自何时收录于AGRIS:
2017
卷:
30 (12
范围:
2020-2026
出版者:
John Wiley & Sons, Ltd
所有题名:
"Decursin in Angelica gigas Nakai (AGN) Enhances Doxorubicin Chemosensitivity in NCI/ADR‐RES Ovarian Cancer Cells via Inhibition of P‐glycoprotein Expression"@eng
其它:
"JOURNAL ARTICLE"
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书目信息

语言:
English
类型:
Journal Article
自何时收录于AGRIS:
2017
卷:
30 (12
范围:
2020-2026
出版者:
John Wiley & Sons, Ltd
所有题名:
"Decursin in Angelica gigas Nakai (AGN) Enhances Doxorubicin Chemosensitivity in NCI/ADR‐RES Ovarian Cancer Cells via Inhibition of P‐glycoprotein Expression"@eng
其它:
"JOURNAL ARTICLE"