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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

فعّال (مزود البيانات قام بتقديم البيانات الوصفية السنة الماضية)
Journal Article

مقال مجلة

Preventive effects of guava (Psidium guajava L.) leaves and its active compounds against α-dicarbonyl compounds-induced blood coagulation  [2007]

Hsieh, C.L.; Lin, Y.C.; Yen, G.C.; Chen, H.Y.;

استعراض النص الكامل

Diabetes is associated with a hypercoagulable state which may accelerate atherosclerosis, thrombosis and the diabetic microvascular complication. Endogenously produced α-dicarbonyl compounds are linked to the pathophysiology of diabetic complications. The effects of α-dicarbonyl compounds on coagulation parameters in vitro and the anticoagulant activities of aqueous extracts from guava leaves were examined. Incubation of plasma with glyoxal or methylglyoxal at 0.1 mM showed a significant decrease in thrombin clotting time (TT) (P < 0.05). However, they exhibited slight prolongation of the prothrombin time (PT) at 0.5 mM and no effect on the activated partial thromboplastin time (APTT). In order to define the action mechanism of the hypercoagulant activity, coagulation factors such as fibrinogen and antithrombin III activity were evaluated. The fibrinogen contents in plasma were decreased slightly with increasing concentrations of glyoxal and methylglyoxal. Moreover, methylglyoxal inhibited antithrombin III activity and over 80% of the activity was lost at 1.2 mM methylglyoxal. In contrast, guava leaf extracts exhibited significant inhibition of TT shortening induced by methylglyoxal. Guava leaf extracts and its active phenolic compounds including ferulic acid, gallic acid and quercetin also displayed a protective effect against methylglyoxal-induced loss of activity of antithrombin III. Thus, guava leaf extracts are a potent antiglycative agent and anticoa
gulant, which can be of great value in the preventive glycation-associated cardiovascular diseases in diabetes.
المجلة
Food chemistry
الرقم التسلسلي المعياري الدولي (ردمد) : 0308-8146

معلومات ببليوغرافية

اللغة:
English
النوع:
Journal Article
في أجريس منذ:
2013
المجلد:
103 issue 2
صفحة البداية:
528
صفحة النهاية:
535
جميع العناوين:
"Preventive effects of guava (Psidium guajava L.) leaves and its active compounds against α-dicarbonyl compounds-induced blood coagulation"@eng
مسائل أخرى:
"Includes references"
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معلومات ببليوغرافية

اللغة:
English
النوع:
Journal Article
في أجريس منذ:
2013
المجلد:
103 issue 2
صفحة البداية:
528
صفحة النهاية:
535
جميع العناوين:
"Preventive effects of guava (Psidium guajava L.) leaves and its active compounds against α-dicarbonyl compounds-induced blood coagulation"@eng
مسائل أخرى:
"Includes references"