AGRIS

Data provider:

Icon data provider

It is the biggest library of agricultural literature in Latvia, the deposit library of the UN Food and Agriculture Organisation and the national centre of the information systems AGRIS and CARIS.

Actif (Le fournisseur de données a soumis des métadonnées au cours de la dernière année civile)
Journal Article

Article de revue

Beef meat and dietary haem promote colon carcinogenesis in rats. Prevention by olive oil and calcium.  [2008]

Santarelli, Raphaelle; Tache, Sylviane; Gueraud, Francoise; Corpet, Denis; Pierre, Fabrice [Corporate Author]

Visualise le texte intégral

Red meat consumption is associated with increased risk of colorectal cancer. We have previously shown that haemin, Hb and red meat promotecarcinogen-induced preneoplastic lesions: aberrant crypt foci (ACF) and mucin-depleted foci (MDF) in rats. We have also shown that dietaryCa, antioxidant mix and olive oil inhibit haemin-induced ACF promotion, and normalize faecal lipoperoxides and cytotoxicity. Here we testedif these strategies are effective also against red meat promotion in dimethylhydrazine-induced rats. Three diets with 60% beef meat were supplementedwith calcium phosphate (31 g/kg), antioxidant agents (rutin and butylated hydroxyanisole, 0·05% each) and olive oil (5 %). ACF,MDF, faecal water cytotoxicity, thiobarbituric acid reactive substances (TBARS) and urinary 1,4-dihydroxynonane mercapturic acid (DHNMA)were measured. Beef meat diet increased the number of ACF (þ30 %) and MDF (þ100 %) (P,0·001), which confirms our previous findings.Promotion was associated with increased faecal water TBARs ( £ 4) and cytotoxicity ( £ 2), and urinary DHN-MA excretion ( £ 15). Cafully inhibited beef meat-induced ACF and MDF promotion, and normalized faecal TBARS and cytotoxicity, but did not reduce urinary DHNMA.Unexpectedly, high-calcium control diet-fed rats had more MDF and ACF in the colon than low-Ca control diet-fed rats. Antioxidant mix andolive oil did not normalize beef meat promotion nor biochemical factors. The results confirm that haem causes promotio
n of colon carcinogenesisby red meat. They suggest that Ca can reduce colorectal cancer risk in meat-eaters. The results support the concept that toxicity associated with theexcess of a useful nutrient may be prevented by another nutrient.
(Revue
British Journal of Nutrition 5 (99), 1000-1006. (2008)

Information bibliographique

Langue:
English
Type:
Journal Article
Sur AGRIS depuis:
2016
Tous les titres:
"Beef meat and dietary haem promote colon carcinogenesis in rats. Prevention by olive oil and calcium."@eng
Loading...

Information bibliographique

Langue:
English
Type:
Journal Article
Sur AGRIS depuis:
2016
Tous les titres:
"Beef meat and dietary haem promote colon carcinogenesis in rats. Prevention by olive oil and calcium."@eng