The article presents the results of the influence of glycyrrhizic acid and its derivatives in various percentages (0.1–1.5%) NaCl and in the post-stress period on the balance of phytohormones and the growth of roots of wheat seedlings. It was found that the treatment of wheat seeds with glycyrrhizic acid prevented salinization-induced inhibition of the mitotic activity of the cells of the root apical meristem and, in the post-stress period, accelerated the repair of root growth processes. The manifestation of the protective effect of glycyrrhizic acid on the growth of wheat root cells is due to its effect on the activity of the hormonal system of seedlings. Salinity negatively affected the balance of phytohormones associated with reversible accumulation of ABA and a decrease in the level of IAA and cytokinins in wheat seedlings. Treatment of wheat seeds with glycyrrhizic acid and its derivatives contributed to the maintenance of the hormonal status of roots under salinity conditions at the level of control plants. The results obtained indicate an important role of glycyrrhizic acid induced rearrangements of the hormonal system in the regulation of wheat plant growth under stress conditions.