The methods of Ribéreau-Gayon and Stonestreet (1966) and Di Stefano et al. (1989) to determine red wine proanthocyanidins were compared. The proanthocyanidin concentrations obtained by the application of these methods are quite different, depending on the varietal origin and age of wine. Because the composition of wine affects the results obtained with the Ribéreau-Gayon and Stonestreet methods, a modification was proposed to eliminate the interferents influence. This modification provides a) the elimination of interferents by absorption of proanthocyanidins on C sub(18) RP cartridge, b) the elution by methanol of absorbed polyphenols and c) the application of Ribéreau-Gayon and Stonestreet method to the eluate. The data obtained by the two methods in question were also compared with the data of polyphenols by Folin Ciocalteu reagent, as well as by absorbance at 280 nm. The two methods of proanthocyanidins determination, applied after elimination of interferents, allow to make similar deductions about the tannic composition of wine