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The Publishing Center Science and Practice publishes non-periodicals, as well as the electronic scientific journal Bulletin of Science and Practice.

فعّال (مزود البيانات قام بتقديم البيانات الوصفية السنة الماضية)
Journal Article

مقال مجلة

N-Methyl-D-Glucoseimine Synthesis Reaction Thermodynamic Properties Calculation  [2020]

Mikhailov, S.; Brovko, R.; Mushinskii, S.; Sulman, M.;

استعراض النص الكامل

The presented article is devoted to thermodynamic calculations of the N-methyl-D-glucosimine reversible formation reaction, an intermediate product for N-methyl-D-glucosamine synthesis, which is widely used in pharmaceutical practice as a ballast or counterion that improves the bioavailability of the main active substance. N-methyl-D-glucosimine is synthesized as a result of the interaction of D-glucose with methylamine in organic solvents, the reaction is reversible, and the yield of the target product depends entirely on the reaction conditions. The use of thermodynamic calculations makes it possible to evaluate the influence of the chemical process conditions on the yield of target products, which in turn contributes to a deeper understanding of the chemical reactions mechanisms. In chemical equilibrium, direct and reverse reactions proceed at equal rates, while the concentrations of products and reagents remain constant. When the reaction proceeds in a closed system, after a certain time, a state of equilibrium occurs, while the reaction does not proceed with a complete transformation of the reagents. This article presents the results of thermodynamic calculations of the reaction for the synthesis of N-methyl-D-glucosimine by the Van Kravlen – Cheremnov method. The Gibbs energy, equilibrium constants, and D-glucose conversion were calculated as activity function of reacting substances. It was shown that an increase in the temperature of the reaction mi
xture from 20 to 160 °C promotes an increase in the conversion of D-glucose from 3 to 32%, and therefore it is possible to recommend carrying out this reaction at elevated temperatures.
المجلة
Bulletin of Science and Practice

معلومات ببليوغرافية

اللغة:
Russian
النوع:
Journal Article
في أجريس منذ:
2020
المجلد:
6
الإصدار:
11
النطاق:
40-46
الناشر:
Publishing Center Science and Practice
جميع العناوين:
"Определение термодинамических характеристик реакции получения N-метил-D-глюкозимина"@rus
"N-Methyl-D-Glucoseimine Synthesis Reaction Thermodynamic Properties Calculation"@eng
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معلومات ببليوغرافية

اللغة:
Russian
النوع:
Journal Article
في أجريس منذ:
2020
المجلد:
6
الإصدار:
11
النطاق:
40-46
الناشر:
Publishing Center Science and Practice
جميع العناوين:
"Определение термодинамических характеристик реакции получения N-метил-D-глюкозимина"@rus
"N-Methyl-D-Glucoseimine Synthesis Reaction Thermodynamic Properties Calculation"@eng