Different dosages (1/4 and 1/2 tsp) of papaya seeds infusion (Trial 1) and varied amounts (50, 40, and 30) of whole papaya seeds (Trial 2) were given orally as dewormer to groups of native chickens which were infected naturally with gastro-intestinal parasites. Results of trial 1 showed that there was a significant (P0.01) reduction in the number of ova in the chicken excreta 2 weeks after the treatment period. Chickens which were given 1/4 tsp of the seed infusion have two adult roundworms and 6 adult tapeworms, while those chickens which were given 1/2 tsp of the seed infusion had one roundworm and four tapeworms. The control chickens had numerous roundworms and tapeworms. In trial 2, there was a significant (P0.01) reduction in the number of ova in the excreta after the treatment period. Chickens which were given 50 seeds of whole papaya seeds had no ova and adult gastrointestinal parasite in the excreta, while those chickens which were given either 40 or 30 whole papaya seeds had two and four tapeworms present in the excreta, respectively