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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

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Journal Article

Artículo de revista

Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: A combined spectroscopic and separation approach with molecular modeling studies  [2011]

Enyedy, Éva A.; Horváth, László; Hetényi, Anasztázia; Tuccinardi, Tiziano; et al.

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The specific binding of carrier ligands of antidiabetic vanadium(IV) and zinc(II) complexes into drug binding pockets of human serum albumin (HSA) has been investigated via displacement reactions of site markers such as warfarin and dansylglycine by different spectroscopic (fluorescence, circular dichroism, NMR) and separation methods (capillary zone electrophoresis, ultrafiltration-UV). Conditional stability constants of the ligands were calculated for the binding at sites I and II of HSA. Binding site I was found to be the primary binding site for 2,6-pyridine dicarboxylic acid (dipic) and picolinic acid (pic), and site II for 6-methylpicolinic acid (6-Mepic) and maltol, although dipic, 6-Mepic and pic displace both site markers at differing extents. The experimental data is complemented by protein–ligand docking calculations for dipic and 6-Mepic which support the observations.
Publicación
Bioorganic & medicinal chemistry
ISSN : 0968-0896

Información bibliográfica

Idioma:
English
Tipo:
Journal Article
En AGRIS desde:
2015
Volumen:
19
Edición:
14
Página inicial:
4202
Página final:
4210
Editorial:
Elsevier Ltd
Todos los títulos:
"Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: A combined spectroscopic and separation approach with molecular modeling studies"@eng
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Información bibliográfica

Idioma:
English
Tipo:
Journal Article
En AGRIS desde:
2015
Volumen:
19
Edición:
14
Página inicial:
4202
Página final:
4210
Editorial:
Elsevier Ltd
Todos los títulos:
"Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: A combined spectroscopic and separation approach with molecular modeling studies"@eng