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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

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Journal Article

Статья в журнале

Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: A combined spectroscopic and separation approach with molecular modeling studies  [2011]

Enyedy, Éva A.; Horváth, László; Hetényi, Anasztázia; Tuccinardi, Tiziano; et al.

Доступ к полному тексту

The specific binding of carrier ligands of antidiabetic vanadium(IV) and zinc(II) complexes into drug binding pockets of human serum albumin (HSA) has been investigated via displacement reactions of site markers such as warfarin and dansylglycine by different spectroscopic (fluorescence, circular dichroism, NMR) and separation methods (capillary zone electrophoresis, ultrafiltration-UV). Conditional stability constants of the ligands were calculated for the binding at sites I and II of HSA. Binding site I was found to be the primary binding site for 2,6-pyridine dicarboxylic acid (dipic) and picolinic acid (pic), and site II for 6-methylpicolinic acid (6-Mepic) and maltol, although dipic, 6-Mepic and pic displace both site markers at differing extents. The experimental data is complemented by protein–ligand docking calculations for dipic and 6-Mepic which support the observations.
Журнал
Bioorganic & medicinal chemistry
ISSN : 0968-0896

Библиографическая информация

Язык:
English
Тип:
Journal Article
В АГРИСе с:
2015
Том:
19
Выпуск:
14
Стартовая страница:
4202
Конечная страница:
4210
Издатель:
Elsevier Ltd
Все названия:
"Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: A combined spectroscopic and separation approach with molecular modeling studies"@eng
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Библиографическая информация

Язык:
English
Тип:
Journal Article
В АГРИСе с:
2015
Том:
19
Выпуск:
14
Стартовая страница:
4202
Конечная страница:
4210
Издатель:
Elsevier Ltd
Все названия:
"Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: A combined spectroscopic and separation approach with molecular modeling studies"@eng