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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

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Journal Article

期刊文章

Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: A combined spectroscopic and separation approach with molecular modeling studies  [2011]

Enyedy, Éva A.; Horváth, László; Hetényi, Anasztázia; Tuccinardi, Tiziano; et al.

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The specific binding of carrier ligands of antidiabetic vanadium(IV) and zinc(II) complexes into drug binding pockets of human serum albumin (HSA) has been investigated via displacement reactions of site markers such as warfarin and dansylglycine by different spectroscopic (fluorescence, circular dichroism, NMR) and separation methods (capillary zone electrophoresis, ultrafiltration-UV). Conditional stability constants of the ligands were calculated for the binding at sites I and II of HSA. Binding site I was found to be the primary binding site for 2,6-pyridine dicarboxylic acid (dipic) and picolinic acid (pic), and site II for 6-methylpicolinic acid (6-Mepic) and maltol, although dipic, 6-Mepic and pic displace both site markers at differing extents. The experimental data is complemented by protein–ligand docking calculations for dipic and 6-Mepic which support the observations.
来自期刊
Bioorganic & medicinal chemistry
ISSN : 0968-0896

书目信息

语言:
English
类型:
Journal Article
自何时收录于AGRIS:
2015
卷:
19
期:
14
起始页:
4202
结束页:
4210
出版者:
Elsevier Ltd
所有题名:
"Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: A combined spectroscopic and separation approach with molecular modeling studies"@eng
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书目信息

语言:
English
类型:
Journal Article
自何时收录于AGRIS:
2015
卷:
19
期:
14
起始页:
4202
结束页:
4210
出版者:
Elsevier Ltd
所有题名:
"Interactions of the carrier ligands of antidiabetic metal complexes with human serum albumin: A combined spectroscopic and separation approach with molecular modeling studies"@eng