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The National Agricultural Library is one of four national libraries of the United States, with locations in Beltsville, Maryland and Washington, D.C. It houses one of the world's largest and most accessible agricultural information collections and serves as the nexus for a national network of state land-grant and U.S. Department of Agriculture field libraries. In fiscal year 2011 (Oct 2010 through Sept 2011) NAL delivered more than 100 million direct customer service transactions.

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Journal Article

Статья в журнале

Mechanisms underlying the diuretic effect of Gomphrena celosioides Mart. (Amaranthaceae)  [2017]

Paulo César; de Paula Vasconcelos; Danilo Ramos; Spessotto; et al.

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Gomphrena celosioides (Amaranthaceae) is a native medicinal plant found in Mato Grosso do Sul State that is used for treating urinary tract and kidney stones. This study aimed to evaluate the diuretic effects of ethanolic extract from G. celosioides (EEGC) on acute and extended diuresis to provide a pharmacological basis for its use in traditional medicine.To evaluate the diuretic and natriuretic activity of EEGC and its mechanism of action in an animal model.EEGC (30, 100 and 300mg/kg) was orally administered in male Wistar rats, and urinary excretion was measured at intervals of up to 8h after administration. To evaluate participation of the nitric oxide (NO), prostaglandin and bradykinin pathways in its effect, respective inhibitors were also administered together with effectives doses of EEGC and compared with control groups. A 7-day model with daily administration and urine measurement was also carried out.Oral administration of doses of 100 and 300 significantly increased urine output after 8h compared to the control group. It was observed this effect is dependent on the NO, prostaglandin and bradykinin pathways because their inhibitors reduced the diuretic effects of EEGC. Moreover, after 7 days of treatment, the effect was sustained and a decrease in serum aldosterone was observed in the extract group.According to the results, G. celosioides extract showed diuretic and natriuretic effects associated with more than one mechanism of action. Consideri
ng that all diuretic drugs are currently available for the treatment of volume and electrolyte disturbances, especially hypertensive status, the present results may have clinical relevance and open new possibilities for the development of new natural diuretics from G. celosioides.
Журнал
Journal of ethnopharmacology
ISSN : 0378-8741

Библиографическая информация

Язык:
English
Тип:
Journal Article
В АГРИСе с:
2017
Том:
202 (4
Экстент/Размер:
85-91
Издатель:
Elsevier B.V.
Все названия:
"Mechanisms underlying the diuretic effect of Gomphrena celosioides Mart. (Amaranthaceae)"@eng
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Библиографическая информация

Язык:
English
Тип:
Journal Article
В АГРИСе с:
2017
Том:
202 (4
Экстент/Размер:
85-91
Издатель:
Elsevier B.V.
Все названия:
"Mechanisms underlying the diuretic effect of Gomphrena celosioides Mart. (Amaranthaceae)"@eng