Journal Article
Dating the onset of some mutations in myostatin gene determining the "double muscled" phenotype in beef cattle [beef cattle breeds; Italy] [2003]
Savarese, M.C. (Università della Tuscia, Viterbo (Italy). Dipartimento di Produzioni Animali); Marchitelli, C. (Università della Tuscia, Viterbo (Italy). Dipartimento di Produzioni Animali); Crisa, A. (Università della Tuscia, Viterbo (Italy). Dipartimento di Produzioni Animali); Valentini, A. (Università della Tuscia, Viterbo (Italy). Dipartimento di Produzioni Animali); et al.
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[Myostatin is a protein codified by GDF8 gene which operates as a negative regulator of muscle growth. In several cattle breeds the occurrence of a not properly working myostatin, often as a consequence of mutations in the third exon, results in "double muscled" phenotype. In some breeds the selection caused the fixation of mutated alleles (Belgian Blue, Piemontese), while in Marchigiana the frequency of such alleles is low. In the present work we have estimated the onset time of the mutation in such breeds by utilizing microsatellite molecular markers in linkage within the same myostatin chromosome (2). The estimated times of onset of the mutations resulted very short in all breeds, particularly the one carried by Marchigiana. In this breed the linkage disequilibrium is still present in a large part of chromosome 2.]
