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Journal Article

Journal Article

Effects of Phloroglucinol Isolated from Ecklonia stolonifera on the Acetaminophen-Metabolizing Enzyme System in Rat  [2000]

Park Jong-Cheol; Hur Jong-Moon Dept. of Oriental Meclicine Resources and Dept. of Food and Nutrition, Sunchon National University, Sunchon 540-742 (Korea Republic);

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Phloroglucinol isolated from Ecklonia stolonifera prevented the acetaminophen (800 mg/kg, i.p.)-induced rats as evidenced by the decreased formation of lipid peroxide. The activities of cytochrome P-450, animopyrine N-demethylase and aniline hydroxylase were not changed by the treatment with phenolic compound as compared with acetaminophen-treated rats. The glutathione S-transferase activity was decreased by the treatment of acetaminophen. This enzyme activity was restored in liver of pretreated-rats given by phloroglucinol. Pretreatment of this compound marked the liver protective activities as recovering the decreased glutathione level and glutathione reductase activity in rats treated with acetaminophen. But gamma-glutamylcystein synthetase activity was not changed. The results suggest that the acetaminophen-induced hepatic lipid peroxidation may be reduced by enhancing the activity of glutathione S-transferase.

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Bibliographic information

Language:
Korean
Type:
Journal Article
In AGRIS since:
2001
Volume:
29
Issue:
3
Start Page:
448
End Page:
452
All titles:
" Effects of Phloroglucinol Isolated from Ecklonia stolonifera on the Acetaminophen-Metabolizing Enzyme System in Rat "
Other:
" Summaries (En, Ko) "
" tables;5 ref;23 "

From the journal

J. Korean Soc. Food Sci. Nutr.

ISSN : 1126-3311