Ducks are highly susceptible to aflatoxin. Aflatoxicosis constitute 20% of all deaths and more common in ducklings of 3-8 week age group. The present study describes the gross and histopathological changes in liver and kidney in ducks with aflatoxicosis. Congestion and haemorrhages in the liver with soft and friable consistency was the predominant gross lesion. Enlargement of the kidney with congestion and reticulation was also seen. Microscopically, liver showed severe fatty change, necrosis, perilobular fibrocytic proliferation and billiary hyperplasia. Kidney revealed degeneration and atrophy of glomerulli.